Signifier® Medical Technologies Hosted a Global Webinar on: “Latest Advances in the Management of Sleep Disordered Breathing”

LONDON, 17th July 2020

Signifier Medical Technologies, an innovator in the sleep disordered breathing market, recently hosted a global webinar with leading world experts in the field of sleep disordered breathing (SDB).

The webinar was centred on “Precision medicine for obstructive sleep apnea and emerging technologies” and it was hosted by Prof. Dr. Peter Cistulli (ResMed Chair in Sleep Medicine at the University of Sydney, Australia) and Prof. Dr. Atul Malhotra, (Research Chief in Pulmonary, Critical Care and Sleep Medicine at UC San Diego, USA).

Prof. Dr. Anshul Sama (Consultant ENT and Sleep Physician at Nottingham University Hospital, UK and inventor of the daytime intraoral neuromuscular electrical stimulation (NMES) technology1-2 for reduction of sleep disordered breathing) also participated to the webinar presenting the eXciteOSA® technology and the new treatment proposed with the eXciteOSA® device.

The webinar shed new light on the SDB space and presented novel clinical data on the new NMES technology associated with eXciteOSA®.

This new data brought together results from a multi-centre clinical study held in tier-1 academic centres at London Teaching Hospital and Spain (University of Navarra) – with c. 115 participants.

The clinical results showed:

  • Significant clinical reductions in objective mild Obstructive Sleep Apnea (OSA) indexes, including AHI, ODI and RDI; and
  • Subjective questionnaires completed by bed partners that reported a substantial reduction in snoring.

This treatment resulted in an improved quality of sleep for both the patients and their partner3.

eXciteOSA® is a non-invasive daytime therapy for the tongue which delivers small contractions that improves muscle function and reduces the physiological collapse of the tongue during sleep. The device is a one size fits all and effective when used for 20 minutes a day for six weeks, with sustained improvement with minimal weekly maintenance.

Patients often find conventional night-time solutions ineffective or difficult to tolerate. With the increasing public and digital awareness of sleep and sleep devices, it is increasingly likely that more patients will be consulting their healthcare professionals on these issues.

eXciteOSA® gives healthcare professionals and patients an effective solution that is easy and convenient to use.

If you missed it live, visit www.exciteosa.com/past-webinars to view previous webinars on-demand and register for future webinars.

About Snoring and OSA

Nearly 1 billion adults aged 30 to 69 are estimated to have obstructive sleep apnea (OSA) globally. There is a strong, clinically proven link between obstructive sleep apnea and co-morbidities like diabetes, hypertension, and strokes. Mild OSA affects over 110 million people in the US and 100 million people in Europe.

Obstructive sleep apnea is marked by recurring collapse of the upper airways during sleep. The most common symptoms are restless sleep, snoring, tiredness during the day, decreased intellectual alertness and personality alterations. Higher risks of cardiovascular diseases and increased mortality rates have been associated with OSA.

Standard therapy of all advanced levels of sleep apnea is with a continuous positive airway pressure (CPAP) device. Many patients find this therapy invasive, and the long-term compliance of CPAP therapy is limited, so there is a demand for new forms of treatment.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as Snoozeal, is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with snoring and sleep disordered breathing conditions. Signifier’s proprietary therapy is the first and only daytime genioglossal (tongue) muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients.1-3

References

  1. Wessolleck E, Bernd E, Dockter S, et al. Intraoral electrical muscle stimulation in the treatment of snoring. Somnologie (Berl). 2018; 22 (Suppl 2): 47–52.
  2. Sama A, et al. Daytime Intraoral Neurostimulation with Snoozeal® for Treatment of Snoring and Mild Sleep Apnea. CHEST Annual Meeting Notes. 2018.
  3. Clinical study of 115 patients with snoring or mild OSA (Apnea- Hypopnea Index (AHI <15). Objective snoring and respiratory parameters were recorded with 2 consecutive WatchPat night sleep studies before and after the use of the device. An intra-oral tongue stimulator (Snoozeal®) device was used for 20mins, once a day for 6-week period

For media enquiries:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier® Medical Technologies Wins iF Design Award 2020 for Design Excellence for eXcite®, the World’s First, Daytime Treatment Device That Tackles the Root Cause of Sleep Apnoea and Snoring

snoozeal product controller and main product

February 25, 2020
– London, United Kingdom – Signifier Medical Technologies Limited, formerly known as eXciteOSA®, is delighted to announce that it has won the prestigious iF DESIGN AWARD for Design Excellence, in the “Product” category, for its novel medical device, eXciteOSA® for patients with sleep apnoea and snoring.

The iF DESIGN AWARD is the oldest independent quality design seal in the world and one of the most important design prizes when it comes to excellence in design. This award exemplifies Signifier Medical Technologies’ commitment to making outstanding, patient-centric design an integral component of the user experience, together with eXciteOSA’s® ergonomic styling, connected smart features and ease of use.

Professor Anshul Sama (FRCS), Founder and Chief Medical Officer of Signifier Medical Technologies and Ear, Nose and Throat Surgeon at the University of Nottingham, was keenly aware of the fact that many of his patients were struggling with conventional treatment options for their sleep apnoea and snoring issues. Based on an understanding of this significant unmet need and working with a talented multidisciplinary team, he created the world’s first, daytime treatment device that tackles the root cause of sleep apnoea – eXciteOSA®.

The eXciteOSA® treatment has been clinically proven with rigorous clinical trials conducted by prestigious institutions showing an objective improvement in sleep quality by reducing sleep apnoea and snoring significantly. 1, 2

Nearly 1 billion adults aged 30 to 69 are estimated to have obstructive sleep apnoea (OSA) globally. There is also a strong, clinically proven link between obstructive sleep apnoea and co-morbidities like diabetes, hypertension and strokes.

Professor Sama commented: “Our team is thrilled to have been awarded such a prestigious honour from iF International Forum Design. eXciteOSA® is a result of a devoted effort by many highly skilled professionals from sleep medicine, maxillofacial surgery, product development, medical engineering, software engineering and regulatory that led to an easy-to-use, effective product that will be readily available to all and workable through a phone app. We are looking forward to bringing eXciteOSA® to market and helping more people improve their quality of sleep with this easy-to-use and effective solution.”

Organized by iF International Forum Design GmbH, the iF Design Award contest started in Germany in 1953. Design submissions are subject to comprehensive evaluation for design, innovativeness, functionality and seven additional categories including product, packaging, communication and professional concepts.

iF Design Award 2020 winners are announced online through the iF Design Award website and iF Design app and winning designs will be presented at the iF Design Exhibition from 2-10 May during Berlin Design Week 2020.

More information about the eXciteOSA® iF DESIGN AWARD can be found in the “Design Excellence” section of the iF WORLD DESIGN GUIDE https://ifworlddesignguide.com

For the eXciteOSA® entry go to: https://ifworlddesignguide.com/search?search=snoozeal#/page/entry/285464-snoozeal

Images of the eXciteOSA® device are available upon request to info@signifiermedical.com

About Snoring and OSA

Nearly 1 billion adults aged 30 to 69 are estimated to have obstructive sleep apnoea (OSA) globally. There is a strong, clinically proven link between obstructive sleep apnoea and co-morbidities like diabetes, hypertension and strokes. Mild OSA affects over 110 million people in the US and 100 million people in Europe.

Obstructive sleep apnoea is marked by recurring collapse of the upper airways during sleep. The most common symptoms are restless sleep, snoring, tiredness during the day and decreased intellectual alertness. Higher risks of cardiovascular diseases and increased mortality rates have been associated with OSA.

Standard therapy of all advanced levels of sleep apnoea is with a continuous positive airway pressure (CPAP) device. Many patients find this therapy invasive, and the long-term compliance of CPAP therapy is limited, so there is a demand for new forms of treatment.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as eXciteOSA®, is a medical technology company focused on the development and commercialisation of innovative and non-invasive solutions for patients with snoring and sleep-disordered breathing conditions. Signifier’s proprietary therapy is the first and only daytime genioglossal (tongue) muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients. 1, 2

For more information, please visit www.snoozeal.com

About the iF DESIGN AWARD

The iF DESIGN AWARD has been a globally recognized trademark when it comes to excellence in design for 67 years. The iF brand enjoys an international reputation as a symbol for outstanding design achievement. The iF DESIGN AWARD is one of the most important design prizes in the world. It honours design achievements in all disciplines: product, packaging, communication and service design, architecture and interior architecture as well as professional concepts. All the award-winning entries are presented in the iF WORLD DESIGN GUIDE, published in the iF design app and exhibited at the iF design exhibition in Berlin.

References

  1. 1. A.Sama et al. Daytime Intraoral Neuromuscular stimulation with Snoozeal® for treatment of Snoring and Mild Sleep Apnea. CHEST Annual Meeting Notes, 2018
  2. 2. E.Wessoleck et al. Intraoral electrical muscle stimulation in the treatment of snoring. Somnologie (Berl). 2018; 22(Suppl 2): 47–52.

For more information, please contact us at:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier® Medical Technologies appoints David Ritscher as Chief Engineer

David brings significant experience in medical devices and consumer wearables, having researched and commercialized products across several sectors, including sleep.

Boston, MA, USA, and London, United Kingdom

January 12, 2020

Signifier Medical Technologies (“Signifier/the Company”), an innovator in the sleep-disordered breathing market, is pleased to announce the appointment of David Ritscher as Chief Engineer with immediate effect. He will be based in Boston and will be responsible for the Company’s hardware and software development, as well as data science capability. David’s appointment ensures that the Company is prepared to meet its ambitious growth plans and continued innovation.

David is a highly effective R&D leader who has led numerous successful medical and consumer implantable and wearable devices. Most recently, David worked at Cambridge Consultants, where he developed systems ranging from physiology monitoring devices to robotic test systems.  He had a focus on predictive analytics applied to disease states.

David RitscherPrior to that, David was Director of Research & Development at Whoop. He led a team of world-class scientists and clinical specialists to develop the world’s most accurate wrist-worn health monitor, which became the official monitor of the NFL, helping athletes to train optimally.

Earlier in his career, David was a Senior Principal Scientist at Medtronic where he released products including an implantable cardiac monitor. He holds 12 patents and has published 26 book chapters and papers.

Akhil Tripathi, CEO of Signifier commented: “I’m excited that we’ve added David, a world-class R&D leader, to fuel our journey to treat patients with sleep-disordered breathing. Over the last six months, we’ve been building our management team so we can deliver on the incredible opportunities in front of us.”

David Ritscher added, “I see Signifier’s vision as potentially one of the greatest breakthroughs with the sleep pandemic we are now facing. I expect eXciteOSA® and the follow-on products to revolutionize how we treat sleep apnea and improve patient health.”

For more information, please contact:

Signifier Medical Technologies LLC
Email: info@signifiermedical.com
Tel: +1 844 645 3672

About Signifier Medical Technologies

Signifier Medical Technologies is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with sleep-disordered breathing conditions and snoring.

Signifier’s proprietary therapy eXciteOSA® is the first and only daytime genioglossal (tongue) muscle-neurostimulation technology for mild obstructive sleep apnea and snoring, supported by clinical data from prestigious and well-recognized universities and academic institutions, that provides a safe and effective treatment for its patients.1-3

About OSA and Snoring

Nearly 1 billion adults aged 30 to 69 years are estimated to have obstructive sleep apnea (OSA) globally. There is a strong, clinically proven link between OSA and co-morbidities like diabetes, hypertension, and strokes. Mild OSA affects over 110 million people in the US and 100 million people in Europe.

Obstructive sleep apnea is marked by the recurring collapse of the upper airways during sleep. The most common symptoms are restless sleep, snoring, tiredness during the day, decreased intellectual alertness, and personality alterations. Higher risks of cardiovascular diseases and increased mortality rates have been associated with OSA.

Standard therapy of all advanced levels of sleep apnea is with a continuous positive airway pressure (CPAP) device. Many patients find this therapy invasive, and the long-term compliance of CPAP therapy is limited, so there is a clear demand for new forms of treatment.

References

  1. White DP. Sleep-related breathing disorder: 2—pathophysiology of obstructive sleep apnoea. Thorax. 1995; 50:797–804. [PubMed: 7570420]
  2. Wessolleck E, Bernd E, Dockter S, et al. Intraoral electrical muscle stimulation in the treatment of snoring. Somnologie (Berl). 2018; 22 (Suppl 2): 47–52.
  3. Sama A, et al. Daytime Intraoral Neurostimulation with Snoozeal® for Treatment of Snoring and Mild Sleep Apnea. CHEST Annual Meeting Notes. 2018.
  4. Clinical study of 115 patients with snoring or mild OSA (Apnea- Hypopnea Index (AHI <15 n=65). Objective snoring and respiratory parameters were recorded with 2 consecutive WatchPat night sleep studies before and after the use of the device. An intra-oral tongue stimulator (Snoozeal®) device was used for 20mins, once a day for 6-week period

Signifier Medical Technologies Announces Participation In JP Morgan 2020 Global Healthcare Conference

snoozeal product controller and main product

London, United Kingdom
October 10, 2019 – Signifier Medical Technologies, a medical technology company developing innovative sleep-disordered breathing products for use in the homecare setting, today announced that the Company’s management will be participating in the JP Morgan Global Healthcare conference 2020 Conference in San Francisco in January 2020.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as eXciteOSA®, is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with snoring and sleep-disordered breathing conditions.

Signifier’s proprietary therapy is the first and only day time genioglossal muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients.

www.snoozeal.com

For media enquiries:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier Medical Technologies Announces Participation In Jefferies 16th European Medtech Conference

snoozeal product controller and main product

London, United Kingdom
August 25, 2019 – Signifier Medical Technologies, a medical technology company developing innovative sleep-disordered breathing products for use in the homecare setting, today announced that the Company’s management will be participating in the Jefferies 16th European MedTech Conference in London in November 2019.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as eXciteOSA®, is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with snoring and sleep-disordered breathing conditions.

Signifier’s proprietary therapy is the first and only day time genioglossal muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients.

www.snoozeal.com

For media enquiries:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier Medical Technologies Announces Participation In Morgan Stanley 2019 Global Medtech Conference

snoozeal product controller and main product

London, United Kingdom

July 15, 2019 – Signifier Medical Technologies, a medical technology company developing innovative sleep-disordered breathing products for use in the homecare setting, today announced that the Company’s management will be participating in the 2019 Global MedTech conference in New York.

Signifier Medical’s Co-founder and CEO, Akhil Tripathi is scheduled to present on Monday, September 9, 2019 at 9:55 a.m. ET at the Morgan Stanley 2019 Global MedTech Conference.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as eXciteOSA®, is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with snoring and sleep-disordered breathing conditions.

Signifier’s proprietary therapy is the first and only day time genioglossal muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients.

www.snoozeal.com

For media enquiries:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier Medical Technologies Announces Participation In Goldman Sachs 2019 European Medtech Conference

snoozeal product controller and main product

London, United Kingdom
July 5, 2019 – Signifier Medical Technologies, a medical technology company developing innovative sleep disordered breathing products for use in the homecare setting, today announced that the Company’s management will be participating in the 16th Goldman Sachs European MedTech Conference in London in September 2019.

About Signifier Medical Technologies

Signifier Medical Technologies, previously known as Snoozeal, is a medical technology company focused on the development and commercialization of innovative and non-invasive solutions for patients with snoring and sleep disordered breathing conditions.

Signifier’s proprietary therapy is the first and only day time genioglossal muscle-neurostimulation technology, with proven clinical data from prestigious and well-recognised universities and academic institutions, that provides a safe and effective treatment for its patients.

www.snoozeal.com

For media enquiries:
info@signifiermedical.com
+44 (0) 207 096 0586

Signifier Medical Technologies Closes an Oversubscribed Series B Funding Round; Driving Innovation in the Sleep Market

snoozeal product controller and main product

LONDON, 17 June 2019

– Signifier Medical Technologies, previously known as eXciteOSA®, an innovator in the sleep-disordered breathing market, today announced it has closed an oversubscribed Series B funding, aiming to invest further in R&D and prepare the company for commercial stage. With this round, Signifier Medical Technologies has raised a total in excess of $13 million since its founding in 2015.

Read the article in full on prnewswire.com